UNDATED (AP) — Duke coach Mike Krzyzewski and Michigan State's Tom Izzo are back in the Final Four. The Blue Devils ended Gonzaga's run in the NCAA men's basketball tournament after the Spartans ousted Louisville.

Freshman Justise Winslow drained a pair of 3-pointers down the stretch and finished with 16 points as top seed Duke beat Gonzaga 66-52 to win the South Region. The Blue Devils turned a four-point, second-half deficit into a 60-51 lead once Winslow hit a trey with 2:28 remaining.

Matt Jones finished with 16 points for Duke, which is in the Final Four for the first time since its 2010 title run. Tyus Jones had 15 points for the Blue Devils, while fellow freshman Jahlil Okafor (jah-LIHL' OH'-kah-fohr) chipped in nine points and eight rebounds.

Krzyzewski is going to the Final Four for the 12th time, matching UCLA's John Wooden for the most by a head coach.

Kyle Wiltjer had 16 points for the Bulldogs, who were seeking their first trip to the national semifinals.

Michigan State captured the East Region as the seventh seed, knocking off Louisville 76-70 in overtime. Bryn Forbes opened OT with a 3-pointer that put the Spartans ahead to stay. Travis Trice paced the Spartans with 17 points, Denzel Valentine added 15 and Forbes wound up with 14 as the Spartans won for the 12th time in their last 15 games.

Izzo has led Michigan State to seven Final Fours, including the 2000 national championship.

Wayne Blackshear scored 28 for Louisville, which was trying for its third Final Four berth in four years.

Duke and Michigan State will open the semifinals Saturday at Indianapolis before top-ranked and unbeaten Kentucky takes on No. 1 seed Wisconsin.

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